Multi-country outbreak of mpox, External situation report

3191 new confirmed mpox cases were reported globally

This is the 49th situation report for the multi-country outbreak of mpox, which provides details on the latest epidemiological trends, including an update on the global mpox epidemiological situation, as of 28 February 2025, the epidemiological situation for mpox in Africa, with data as of 16 March 2025 and the operational response updates and updates on imported mpox cases as of 21 February 2025.
Highlights

Updated global surveillance data show that 3191 new confirmed mpox cases were reported globally to WHO for February 2025, an 18.2% decline from the preceding month, and most cases (88%) were detected in the African Region.
In the last six weeks, Uganda has reported the highest number of confirmed mpox cases globally, with up to 300 new cases per week.
The Democratic Republic of the Congo continues to be cumulatively the most affected country in the Region since the beginning of the outbreak. The number of suspected cases is plateauing and confirmed cases have
decreased in recent weeks, however it is unclear if this reflects a real decline given reductions in testing in recent weeks. Both clade Ia and Ib continue to circulate in the country.
Burundi shows a consistent decreasing trend of confirmed cases with less than 50 new cases per week, down from over 200 cases per week at its peak, and an overall very low case fatality ratio with one death among 3645 reported cases.
Brazil, the Republic of Congo and the United Republic of Tanzania have reported their first cases of mpox due to clade Ib MPXV.
The Republic of Congo is the first country where co-circulation of clade Ia and Ib MPXV has been documented outside of the Democratic Republic of the Congo.