Since mid-February 2025, according to data available from sentinel sites, global SARS-CoV-2 activity has been increasing, with the test positivity rate reaching 11%, levels that have not been observed since July 2024.
This rise is primarily observed in countries in the Eastern Mediterranean, South-East Asia, and Western Pacific regions.
Since early 2025, global SARS-CoV-2 variant trends have slightly shifted. Circulation of LP.8.1 has been declining, and reporting of NB.1.8.1, a Variant Under Monitoring, is increasing, reaching 10.7% of global sequences reported as of mid-May.
Recent increases in SARS-CoV-2 activity are broadly consistent with levels observed during the same period last year, however, there still lacks a clear seasonality in SARS-CoV-2 circulation, and surveillance is limited. Continued monitoring is essential.
WHO advises all Member States to continue applying a risk-based, integrated approach to managing COVID-19 as outlined in the Director-General’s Standing Recommendations. As part of comprehensive COVID-19 control programmes, vaccination remains a key intervention for preventing severe disease and death from COVID-19, particularly among at-risk groups.
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